Chagas Disease (Other Keyword)
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Challenges of Using NGS to Detect T. cruzi in Human Remains from Pre-Columbian South America (2017)
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The trypanosomatid parasites are responsible for devastating human disease worldwide. In the Americas, Trypanosoma cruzi is the causative agent of Chagas Disease (CD), the most epidemic zoonosis in Latin America today. The clinical manifestations of CD, however, have been recognized in archaeological human remains from South America as early as 9,000 years ago. We present preliminary results of a project that applies paleogenomic methods, including targeted enrichment and next-generation...