Molecular Disease characterization in a pre-Columbian Indigenous population of Punta Candelero, Puerto Rico.

Summary

Skeletal remains belonging to a Late Saladoid population from Punta Candelero site (AD 640-1200), southeast Puerto Rico were used for the detection of Pathogens. Previous studies have established the presence of trace genetic indicators of molecular disease in skeletal remains, such as syphilis and tuberculosis, with associated history or pathology. In this study, we are investigating the presence of various pathogens associated with pre-Columbian Indigenous populations of Puerto Rico. Paleopathology and preservation were a significant factor in sample selection. Characterization of the pathogen component of the ancient DNA was initially directed toward the detection of oral infections consistent with paleopathology and Neglected Tropical Diseases (NTDs) hypothesized to be widespread amongst the population. NTDs are a group of bacterial, viral and parasitic diseases, caused by known pathogens often with an unknown phylogenetic origin. Using sensitive ancient DNA amplification and sequencing techniques we have assayed this population to determine a pathogen Index for each individual and the population overall. We present preliminary results in compliment to existing archaeological information on the disease dynamics of this indigenous population to generate a comprehensive picture of the islands’ complex pre-Columbian past.

This Resource is Part of the Following Collections

• Society for American Archaeology 82nd Annual Meeting, Vancouver, BC (2017)

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Record Identifiers

Abstract Id(s): 17206